Hi seekerom, there is not much difference between both profile, one profile will assume your batteries will be empty at 3.0v and full at 4.2v. The other profile will tell you your batteries are empty at 3.2v and full at 4.2v. If you like to change your batteries around 3.2v or higher then the profile 3.2v-to-4.2v should be used. If you like to change your batteries around 3.0v then you should consider the 3.0v-to-4.2v profile. It's only a matter of what you prefer in your all day usage, it does not affect any other things than the battery percentage bar on the screen and when the dna will start to tell you "low battery" or when the battery percentage bar will start blinking. All batteries are the same with my profiles, no matter how much mAh they have they are all compatible, 4.2v is 100% charged and 3.2v/3.0v is 0%. You will need to play with the "cell soft cutoff" in escribe to really tell your dna when to stop to drain your battery. By default if I remember it's around 2.7v so you should be able to drain your batteries down to 3.0v before your dna slow down on vaping. You should probably change your batteries before that to extend their lifetime but it's up to you, you can drain the batteries down to 3.0v with a cell soft cutoff at 2.8v. I tested my profiles on a hCigar VT75 with a 26650 efest 4200mAh, then used a 18650 VTC5A battery in it, and then I also tested my profiles on a DNA Therion 75W using 2x 18650 Parallel batteries VTC6. I could use the same profile no matter what battery I choose, it's universal.