@WayneoCan you please post a link to SP45.1 INT?
I'm only finding the 2.0 SP30.5 as being the latest, in the Early Firmware and EScribe Suite thread.
@Dobber - I'm on a M1 Mac running the latest macOS. I just connected and worked with multiple Hyperion (100C) units, mostly successfully. I only see the Firmware issue when I try to hide a profile (EScribe > General tab). As you, I'm also seeing no 100C option in the Apply Service Pack menu.